DegronMD - Q8NFW5(DMBX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q32K	TCGA-55-7994	LUAD	TCGA	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.2222
p.Q32K	DO45311	LUAD	ICGC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.2222
p.D36N	TCGA-AX-A2HC	UCEC	TCGA	DYR	CBL_MET	36:38	Mutation altering degron motif	0.6932
p.D36N	TCGA-FD-A6TG	BLCA	TCGA	DYR	CBL_MET	36:38	Mutation altering degron motif	0.6932
p.D36N	DO49760	BLCA	ICGC	DYR	CBL_MET	36:38	Mutation altering degron motif	0.6932
p.D36N	DO41572	UCEC	ICGC	DYR	CBL_MET	36:38	Mutation altering degron motif	0.6932
p.E48K	TCGA-DK-A2I4	BLCA	TCGA	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.0556
p.E48K	DO465	BLCA	ICGC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.0556
p.S40L	TCGA-DK-A6B6	BLCA	TCGA	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.2778
p.S40L	DO48576	BLCA	ICGC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.2778
p.A43V	DO222737	COCA	ICGC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1944
p.A43V	SIDM00596	Endometrial Carcinoma	GDSC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1944
p.A43V	ACH-000941	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1944
p.A43V	ACH-000954	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1944
p.A43V	ACH-001517	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1944
p.A43V	HEC-1	endometrium	COSMIC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1944
p.R38Q	DO229010	COCA	ICGC	DYR	CBL_MET	36:38	Mutation altering degron motif	0.7329
p.L46F	DO229035	LICA	ICGC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1111
p.A43E	DO47068	RECA	ICGC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1944
p.A28G	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1111
p.A28G	ACH-000853	Lung Cancer	CCLE	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1111
p.A28G	NCI-H661	lung	COSMIC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1111
p.Q30K	SIDM00054	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1667
p.Q30K	ACH-001619	Gallbladder Cancer	CCLE	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1667
p.Q30K	ACH-002185	Pancreatic Cancer	CCLE	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1667
p.Q30K	PL18	pancreas	COSMIC	DYR	CBL_MET	36:38	Mutation rewiring degron network	0.1667

Kaplan plot for DMBX1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMBX1

UniProt ID: Q8NFW5

Entrez ID: 127343

Protein name: Diencephalon/mesencephalon homeobox protein 1 (Orthodenticle homolog 3) (Paired-like homeobox protein DMBX1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMBX1 in