DegronMD - Q8NFZ3(NLGN4Y)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E602D	TCGA-50-5941	LUAD	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.C756Y	TCGA-56-A62T	LUSC	TCGA	PPDY	ITCH	757:760	Mutation rewiring degron network	0.3056
p.S608L	TCGA-66-2768	LUSC	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.6556
p.T763M	TCGA-AA-3506	COAD	TCGA	PPDY	ITCH	757:760	Mutation rewiring degron network	0.25
p.S620L	TCGA-BB-4225	HNSC	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0833
p.E602K	TCGA-D3-A2JG	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.L762I	TCGA-EE-A2A2	SKCM	TCGA	PPDY	ITCH	757:760	Mutation rewiring degron network	0.2778
p.R766Q	SIDM02033	Colorectal Carcinoma	GDSC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1667
p.P614H	SIDM00216	Colorectal Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.P614H	SNU-175	large intestine	COSMIC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons