DegronMD - Q8NGY2(OR6K2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V315A	TCGA-A5-A0G2	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.2778
p.V315A	TCGA-BG-A0M4	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.2778
p.V315A	DO228813	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.2778
p.V315A	DO41686	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.2778
p.V315A	DO41235	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.2778
p.P317Q	TCGA-AO-A124	BRCA	TCGA	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation altering degron motif	0.7035
p.P317Q	DO225369	BRCA	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation altering degron motif	0.7035
p.P317Q	DO1287	BRCA	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation altering degron motif	0.7035
p.Q308R	TCGA-CC-A7IH	LIHC	TCGA	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.0833
p.Q308R	DO52181	LIHC	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.0833
p.F312L	TCGA-D5-6920	COAD	TCGA	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.1944
p.F312L	DO8127	COAD	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.1944
p.G307C	TCGA-DF-A2KN	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.0556
p.G307C	DO223282	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.0556
p.V315I	TCGA-KK-A8IA	PRAD	TCGA	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.2778
p.V315I	DO233550	PRAD	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.2778
p.V315I	DO219325	PRAD	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.2778
p.G318V	TCGA-MP-A4TA	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation altering degron motif	0.6421
p.G318V	DO45314	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation altering degron motif	0.6421
p.I311L	TCGA-RC-A6M6	LIHC	TCGA	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.1667
p.I311L	DO223917	LIHC	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.1667
p.P317L	TCGA-Y6-A9XI	PRAD	TCGA	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation altering degron motif	0.7582
p.P317L	DO223664	PRAD	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation altering degron motif	0.7582
p.K322N	DO52582	BOCA	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.3056
p.T319I	DO50970	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation altering degron motif	0.7078
p.V315L	DO231155	LUSC	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.2778
p.S314F	DO222837	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.25
p.F313V	DO48921	PBCA	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation rewiring degron network	0.2222
p.G318E	DO229502	SKCA	ICGC	PGTSS	DEG_SPOP_SBC_1	317:321	Mutation altering degron motif	0.6087

Kaplan plot for OR6K2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OR6K2

UniProt ID: Q8NGY2

Entrez ID: 81448

Protein name: Olfactory receptor 6K2 (Olfactory receptor OR1-17)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for OR6K2 in