DegronMD - Q8TBH0(ARRDC2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R381C	TCGA-2W-A8YY	CESC	TCGA	PPLY	ITCH	385:388	Mutation rewiring degron network	0.2222
p.E337Q	TCGA-49-4494	LUAD	TCGA	PPEY	ITCH	339:342	Mutation rewiring degron network	0.2778
p.E337Q	TCGA-FU-A40J	CESC	TCGA	PPEY	ITCH	339:342	Mutation rewiring degron network	0.2778
p.E350K	TCGA-4Z-AA7W	BLCA	TCGA	PPEY	ITCH	339:342	Mutation rewiring degron network	0.1111
p.E390K	TCGA-4Z-AA7W	BLCA	TCGA	PPLY	ITCH	385:388	Mutation rewiring degron network	0.2778
p.I377S	TCGA-5P-A9JW	KIRP	TCGA	PPLY	ITCH	385:388	Mutation rewiring degron network	0.1111
p.E379Q	TCGA-85-8052	LUSC	TCGA	PPLY	ITCH	385:388	Mutation rewiring degron network	0.1667
p.P395Q	TCGA-D3-A3CE	SKCM	TCGA	PPLY	ITCH	385:388	Mutation rewiring degron network	0.1389
p.R335W	TCGA-SL-A6JA	UCEC	TCGA	PPEY	ITCH	339:342	Mutation rewiring degron network	0.2222
p.E345K	DO218984	BLCA	ICGC	PPEY	ITCH	339:342	Mutation rewiring degron network	0.25
p.E345K	DO222414	BTCA	ICGC	PPEY	ITCH	339:342	Mutation rewiring degron network	0.25
p.E385K	DO218984	BLCA	ICGC	PPLY	ITCH	385:388	Mutation altering degron motif	0.7022
p.D343N	DO228307	BRCA	ICGC	PPEY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.E332Q	DO44314	CESC	ICGC	PPEY	ITCH	339:342	Mutation rewiring degron network	0.1389
p.E332Q	DO24245	LUAD	ICGC	PPEY	ITCH	339:342	Mutation rewiring degron network	0.1389
p.R376C	DO223732	CESC	ICGC	PPLY	ITCH	385:388	Mutation rewiring degron network	0.0833
p.L391P	DO230334	COCA	ICGC	PPLY	ITCH	385:388	Mutation rewiring degron network	0.25
p.L391P	DO227999	COCA	ICGC	PPLY	ITCH	385:388	Mutation rewiring degron network	0.25
p.L391P	DO229013	COCA	ICGC	PPLY	ITCH	385:388	Mutation rewiring degron network	0.25
p.L391P	DO229016	COCA	ICGC	PPLY	ITCH	385:388	Mutation rewiring degron network	0.25
p.R398H	DO234199	ESAD	ICGC	PPLY	ITCH	385:388	Mutation rewiring degron network	0.0556
p.A342V	DO234350	ESAD	ICGC	PPEY	ITCH	339:342	Mutation altering degron motif	0.6936
p.R376H	DO233287	GACA	ICGC	PPLY	ITCH	385:388	Mutation rewiring degron network	0.0833
p.D394Y	DO229028	LICA	ICGC	PPLY	ITCH	385:388	Mutation rewiring degron network	0.1667
p.P390Q	DO37405	SKCM	ICGC	PPLY	ITCH	385:388	Mutation rewiring degron network	0.2778
p.R330W	DO219787	UCEC	ICGC	PPEY	ITCH	339:342	Mutation rewiring degron network	0.0833
p.Q378E	ACH-001652	Endometrial/Uterine Cancer	CCLE	PPLY	ITCH	385:388	Mutation rewiring degron network	0.1389

Kaplan plot for ARRDC2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARRDC2

UniProt ID: Q8TBH0

Entrez ID: 27106

Protein name: Arrestin domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARRDC2 in