DegronMD - Q8TBK6(ZCCHC10)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T108A	TCGA-A5-A0GP	UCEC	TCGA	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.7139
p.D156G	TCGA-FV-A2QR	LIHC	TCGA	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.7198
p.E111Q	DO219093	BLCA	ICGC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.6744
p.T120N	DO225391	BRCA	ICGC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.T120N	DO229031	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.S155P	DO20819	KIRP	ICGC	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.6752
p.H100N	DO228986	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.H100N	DO229036	LICA	ICGC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.K156N	DO220875	MELA	ICGC	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.6918
p.T105A	DO229122	NKTL	ICGC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.25
p.A100D	DO220005	SARC	ICGC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.S111G	DO47819	STAD	ICGC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.6993
p.D166G	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0556
p.D166G	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0556
p.S115G	SIDM00151	Ovarian Carcinoma	GDSC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.25
p.S115G	IGROV-1	ovary	COSMIC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.25
p.S121N	SIDM00516	Melanoma	GDSC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0833
p.S121N	MZ7-mel	skin	COSMIC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0833
p.E143K	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0833
p.E143K	KYSE-450	oesophagus	COSMIC	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0833
p.D104N	ACH-000758	Gastric Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.2222
p.E107K	ACH-000865	Esophageal Cancer	CCLE	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.3056
p.E107K	KYSE-450	oesophagus	COSMIC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.3056
p.K151T	ACH-001081	Colon/Colorectal Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.3056
p.K151T	HCC2998	large intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.3056
p.K155N	ACH-002253	Lymphoma	CCLE	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.6918
p.K155N	JSC-1	haematopoietic and lymphoid tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.6918
p.K165T	HCC2998	large intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0833
p.S99N	MZ7-mel	skin	COSMIC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation substituting flanking lysine	0.1944
p.S109G	IGROV-1	ovary	COSMIC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.6993
p.D144G	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1111
p.S109C	MDA-MB-330	breast	COSMIC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation altering degron motif	0.7541
p.H100R	AN3-CA	endometrium	COSMIC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.1111
p.S115N	MZ7-mel	skin	COSMIC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.25
p.E121K	KYSE-450	oesophagus	COSMIC	VTSSS	DEG_SPOP_SBC_1	108:112	Mutation rewiring degron network	0.0833
p.D160G	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZCCHC10

UniProt ID: Q8TBK6

Entrez ID: 54819

Protein name: Zinc finger CCHC domain-containing protein 10

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZCCHC10 in