DENND10
UniProt ID: Q8TCE6
Entrez ID: 404636
Protein name: DENN domain-containing protein 10 (Protein FAM45A)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bou...
FUNCTION: Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form. {ECO:0000269|PubMed:30771381}.
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GO - Biological processes (BP):
endosome transport via multivesicular body sorting pathway [GO:0032509]; protein transport [GO:0015031]; regulation of early endosome to late endosome transport [GO:2000641]...
endosome transport via multivesicular body sorting pathway [GO:0032509]; protein transport [GO:0015031]; regulation of early endosome to late endosome transport [GO:2000641]
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GO - Molecular function (MF):
guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]...
guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase binding [GO:0031267]
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GO - Cellular component (CC):
late endosome [GO:0005770]...
late endosome [GO:0005770]
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DENND10
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Kaplan plot for DENND10 in
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*NOTE: the Kaplan plots were collected from OncoLnc