DegronMD - Q8TE73(DNAH5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M4363I	TCGA-AA-3695	COAD	TCGA	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.1944
p.M4363I	DO10694	COAD	ICGC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.1944
p.V4376A	TCGA-BS-A0U8	UCEC	TCGA	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.1944
p.V4376A	DO41380	UCEC	ICGC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.1944
p.E4378K	TCGA-D3-A2JC	SKCM	TCGA	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.1389
p.E4378K	DO47578	SKCM	ICGC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.1389
p.D4362N	TCGA-DA-A1I7	SKCM	TCGA	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.1667
p.D4362N	DO37951	SKCM	ICGC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.1667
p.V4372A	TCGA-E6-A1LX	UCEC	TCGA	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.3056
p.V4372A	DO41020	UCEC	ICGC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.3056
p.P4373S	TCGA-ER-A19N	SKCM	TCGA	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.2778
p.P4373S	DO37452	SKCM	ICGC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.2778
p.Q4381K	DO228948	LICA	ICGC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.0556
p.E4378V	DO23452	LINC	ICGC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.1389
p.R4358W	DO50685	ORCA	ICGC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.0556
p.R4358W	SIDM00399	Head and Neck Carcinoma	GDSC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.0556
p.R4358W	ACH-001228		CCLE	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.0556
p.R4358W	SCC90	upper aerodigestive tract	COSMIC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.0556
p.A4360D	DO35678	PBCA	ICGC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.1111
p.Q4381H	SIDM00230	Small Cell Lung Carcinoma	GDSC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.0556
p.Q4381H	ACH-002145	Lung Cancer	CCLE	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.0556
p.Q4381H	IST-SL2	lung	COSMIC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.0556
p.Q4381E	ACH-000465	Skin Cancer	CCLE	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.0556
p.E4375D	LS-180	large intestine	COSMIC	PPDY	ITCH	4368:4371	Mutation rewiring degron network	0.2222

Kaplan plot for DNAH5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAH5

UniProt ID: Q8TE73

Entrez ID: 1767

Protein name: Dynein axonemal heavy chain 5 (Axonemal beta dynein heavy chain 5) (Ciliary dynein heavy chain 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAH5 in