DegronMD - Q8TEB1(DCAF11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R418Q	TCGA-A5-A0VQ	UCEC	TCGA	DYR	CBL_MET	406:408	Mutation rewiring degron network	0.0556
p.A416V	TCGA-AX-A06F	UCEC	TCGA	DYR	CBL_MET	406:408	Mutation rewiring degron network	0.1111
p.R408W	TCGA-WE-AAA4	SKCM	TCGA	DYR	CBL_MET	406:408	Mutation altering degron motif	0.8634
p.R408W	SIDM00666	Glioma	GDSC	DYR	CBL_MET	406:408	Mutation altering degron motif	0.8634
p.R408W	ACH-000067	Brain Cancer	CCLE	DYR	CBL_MET	406:408	Mutation altering degron motif	0.8634
p.R408W	Hs683	central nervous system	COSMIC	DYR	CBL_MET	406:408	Mutation altering degron motif	0.8634
p.A399D	TCGA-WJ-A86L	LIHC	TCGA	DYR	CBL_MET	406:408	Mutation rewiring degron network	0.1389
p.S402L	DO224985	BRCA	ICGC	DYR	CBL_MET	406:408	Mutation rewiring degron network	0.2222
p.S402L	DO222638	MELA	ICGC	DYR	CBL_MET	406:408	Mutation rewiring degron network	0.2222
p.S402L	DO52412	UCEC	ICGC	DYR	CBL_MET	406:408	Mutation rewiring degron network	0.2222
p.W403L	DO37782	SKCM	ICGC	DYR	CBL_MET	406:408	Mutation rewiring degron network	0.25
p.R408Q	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	406:408	Mutation altering degron motif	0.7329
p.R408Q	ACH-002238	Leukemia	CCLE	DYR	CBL_MET	406:408	Mutation altering degron motif	0.7329
p.R408Q	GR-ST	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	406:408	Mutation altering degron motif	0.7329
p.S400R	ASH-3	thyroid	COSMIC	DYR	CBL_MET	406:408	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons