DegronMD - Q8TF46(DIS3L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S380T	TCGA-20-1687	OV	TCGA	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.1389
p.Q363H	TCGA-98-8021	LUSC	TCGA	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.1111
p.T368I	TCGA-PG-A917	UCEC	TCGA	DYR	CBL_MET	371:373	Mutation blocking phosphorylation signal	0.6944
p.T368I	SIDM02039	Colorectal Carcinoma	GDSC	DYR	CBL_MET	371:373	Mutation blocking phosphorylation signal	0.6944
p.T368I	ACH-000999	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	371:373	Mutation blocking phosphorylation signal	0.6944
p.E377Q	DO48576	BLCA	ICGC	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.2222
p.E377Q	MDA-MB-453	breast	COSMIC	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.2222
p.M363V	DO10140	COAD	ICGC	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.1111
p.E378K	DO37543	SKCM	ICGC	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.1944
p.Q382R	SIDM00537	Colorectal Carcinoma	GDSC	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.0833
p.Q382R	ACH-000982	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.0833
p.Q382R	ACH-001345	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.0833
p.Q382R	GP5d	large intestine	COSMIC	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.0833
p.R378Q	SIDM01588	Endometrial Carcinoma	GDSC	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.1944
p.R378Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.1944
p.N366H	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.1944
p.N366H	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	371:373	Mutation rewiring degron network	0.1944
p.P376L	Mewo	skin	COSMIC	DYR	CBL_MET	371:373	Mutation substituting flanking lysine	0.3611
p.P376S	Mewo	skin	COSMIC	DYR	CBL_MET	371:373	Mutation substituting flanking lysine	0.3611

Kaplan plot for DIS3L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DIS3L

UniProt ID: Q8TF46

Entrez ID: 115752

Protein name: DIS3-like exonuclease 1 (EC 3.1.13.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DIS3L in