DegronMD - Q8WUH2(TGFBRAP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A845S	TCGA-85-8071	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1667
p.A845S	DO26755	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1667
p.N850K	TCGA-A8-A07L	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.3056
p.N850K	DO2377	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.3056
p.G857D	TCGA-AA-A010	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.2778
p.E406V	TCGA-AX-A2HC	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.0556
p.E406V	DO41572	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.0556
p.E406V	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.0556
p.E406V	ACH-000451	Lung Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.0556
p.E406V	NCI-H2085	lung	COSMIC	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.0556
p.T860S	TCGA-BA-A4IF	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1944
p.T860S	DO49043	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1944
p.A845T	TCGA-CG-4465	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1667
p.A845T	DO233935	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1667
p.A845T	DO38627	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1667
p.A845T	ACH-001513	Cervical Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1667
p.H405Y	TCGA-E2-A14Z	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.0833
p.H405Y	DO4221	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.0833
p.P402S	TCGA-EB-A5UN	SKCM	TCGA	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1667
p.P402S	DO47267	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1667
p.S400F	TCGA-EK-A3GK	CESC	TCGA	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.2222
p.S400F	DO49964	CESC	ICGC	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.2222
p.L404V	TCGA-GM-A2D9	BRCA	TCGA	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1111
p.L404V	DO4810	BRCA	ICGC	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1111
p.R859Q	TCGA-IS-A3KA	SARC	TCGA	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.2222
p.R859Q	DO220172	SARC	ICGC	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.2222
p.P392H	DO227549	COCA	ICGC	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.7694
p.T849K	DO229015	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation blocking phosphorylation signal	0.7222
p.S846T	DO46329	OV	ICGC	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation blocking phosphorylation signal	0.6389
p.S846T	SIDM00217	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation blocking phosphorylation signal	0.6389
p.S846T	ACH-000999	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation blocking phosphorylation signal	0.6389
p.S846T	SNU-1040	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	851:855	Mutation blocking phosphorylation signal	0.6389
p.R399Q	SIDM00660	Colorectal Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.25
p.R399Q	ACH-000985	Colon/Colorectal Cancer	CCLE	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.25
p.R399Q	LS-411N	large intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.25

Kaplan plot for TGFBRAP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TGFBRAP1

UniProt ID: Q8WUH2

Entrez ID: 9392

Protein name: Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TGFBRAP1 in