DegronMD - Q8WUU8(TMEM174)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R243H	TCGA-06-0192	GBM	TCGA	PPPY	ITCH	232:235	Mutation rewiring degron network	0.1111
p.R243H	DO13420	GBM	ICGC	PPPY	ITCH	232:235	Mutation rewiring degron network	0.1111
p.E223K	TCGA-18-5595	LUSC	TCGA	PPPY	ITCH	232:235	Mutation rewiring degron network	0.0833
p.E223K	DO27373	LUSC	ICGC	PPPY	ITCH	232:235	Mutation rewiring degron network	0.0833
p.S231C	TCGA-5C-A9VH	LIHC	TCGA	PPPY	ITCH	232:235	Mutation rewiring degron network	0.3056
p.S231C	DO52166	LIHC	ICGC	PPPY	ITCH	232:235	Mutation rewiring degron network	0.3056
p.E236G	TCGA-C5-A1ML	CESC	TCGA	PPPY	ITCH	232:235	Mutation rewiring degron network	0.3056
p.E236G	DO51592	CESC	ICGC	PPPY	ITCH	232:235	Mutation rewiring degron network	0.3056
p.M176K	TCGA-DD-A73B	LIHC	TCGA	PPQY	ITCH	179:182	Mutation rewiring degron network	0.25
p.M176K	DO48592	LIHC	ICGC	PPQY	ITCH	179:182	Mutation rewiring degron network	0.25
p.G170R	TCGA-EB-A5UN	SKCM	TCGA	PPQY	ITCH	179:182	Mutation rewiring degron network	0.0833
p.G170R	DO47267	SKCM	ICGC	PPQY	ITCH	179:182	Mutation rewiring degron network	0.0833
p.Y183H	DO221220	AML	ICGC	PPQY	ITCH	179:182	Mutation rewiring degron network	0.3056
p.Y182H	DO874	BOCA	ICGC	PPQY	ITCH	179:182	Mutation altering degron motif	0.7229
p.A175T	DO234173	ESAD	ICGC	PPQY	ITCH	179:182	Mutation rewiring degron network	0.2222
p.A175T	SIDM01749	Osteosarcoma	GDSC	PPQY	ITCH	179:182	Mutation rewiring degron network	0.2222
p.P242L	DO50970	LICA	ICGC	PPPY	ITCH	232:235	Mutation rewiring degron network	0.1389
p.P234S	DO222363	MELA	ICGC	PPPY	ITCH	232:235	Mutation altering degron motif	0.5641
p.R243C	DO222554	MELA	ICGC	PPPY	ITCH	232:235	Mutation rewiring degron network	0.1111
p.R243C	DO222753	MELA	ICGC	PPPY	ITCH	232:235	Mutation rewiring degron network	0.1111
p.P180T	SIDM01133	Other Solid Cancers	GDSC	PPQY	ITCH	179:182	Mutation altering degron motif	0.7031
p.P179H	SIDM00118	Colorectal Carcinoma	GDSC	PPQY	ITCH	179:182	Mutation altering degron motif	0.7694
p.P179H	HCC2998	large intestine	COSMIC	PPQY	ITCH	179:182	Mutation altering degron motif	0.7694
p.E224Q	SIDM00528	Breast Carcinoma	GDSC	PPPY	ITCH	232:235	Mutation rewiring degron network	0.1111
p.E224Q	ACH-000934	Breast Cancer	CCLE	PPPY	ITCH	232:235	Mutation rewiring degron network	0.1111
p.E224Q	MDA-MB-361	breast	COSMIC	PPPY	ITCH	232:235	Mutation rewiring degron network	0.1111
p.G170A	SIDM01757	Bladder Carcinoma	GDSC	PPQY	ITCH	179:182	Mutation rewiring degron network	0.0833
p.G170A	ACH-000741	Bladder Cancer	CCLE	PPQY	ITCH	179:182	Mutation rewiring degron network	0.0833
p.G171V	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PPQY	ITCH	179:182	Mutation rewiring degron network	0.1111
p.G171V	ACH-000851	Lung Cancer	CCLE	PPQY	ITCH	179:182	Mutation rewiring degron network	0.1111
p.D189Y	SIDM01611	Endometrial Carcinoma	GDSC	PPQY	ITCH	179:182	Mutation rewiring degron network	0.1389
p.D189Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPQY	ITCH	179:182	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM174

UniProt ID: Q8WUU8

Entrez ID: 134288

Protein name: Transmembrane protein 174

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM174 in