DegronMD - Q8WWN9(IPCEF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A184T	TCGA-19-5956	GBM	TCGA	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7139
p.A184T	TCGA-F7-A624	HNSC	TCGA	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7139
p.A184T	DO13863	GBM	ICGC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7139
p.A184T	DO44440	HNSC	ICGC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7139
p.G193V	TCGA-EE-A2MD	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1667
p.G193V	DO37851	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1667
p.Q177P	TCGA-EO-A22R	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1667
p.Q177P	DO42713	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1667
p.L179F	TCGA-FS-A1ZP	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.2222
p.L179F	DO37703	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.2222
p.S174F	TCGA-FW-A3R5	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.0833
p.S174F	DO37406	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.0833
p.Q175E	TCGA-VQ-AA64	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1111
p.Q175E	DO222381	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1111
p.T194M	SIDM00216	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1389
p.T194M	ACH-000989	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1389
p.T194M	SNU-175	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1389
p.S186L	SIDM00545	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7667
p.S186L	ACH-000987	Skin Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7667
p.S186L	Mewo	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7667
p.S185P	SIDM01112	Osteosarcoma	GDSC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.6752
p.S185P	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.6752
p.S185P	SIDM00254	Neuroblastoma	GDSC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.6752
p.S185P	SIDM00907	Burkitt's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.6752
p.S185P	SIDM00628	Breast Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.6752
p.S185P	SIDM01664	Prostate Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.6752
p.A181V	SIDM01588	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.2778
p.A181V	ACH-000993	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.2778
p.D195N	HCT-15	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1111
p.P183S	COLO-800	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.6752
p.F197Y	LN-18	central nervous system	COSMIC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.0556
p.T193M	SNU-175	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation rewiring degron network	0.1667
p.S185L	Mewo	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	183:187	Mutation altering degron motif	0.7667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IPCEF1

UniProt ID: Q8WWN9

Entrez ID: 26034

Protein name: Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IPCEF1 in