DegronMD - Q8WWU5(TCP11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V17I	TCGA-AX-A1CE	UCEC	TCGA	PPKY	ITCH	9:12	Mutation rewiring degron network	0.1944
p.V17I	TCGA-EY-A215	UCEC	TCGA	PPKY	ITCH	9:12	Mutation rewiring degron network	0.1944
p.N15K	DO229015	LICA	ICGC	PPKY	ITCH	9:12	Mutation rewiring degron network	0.25
p.P11T	DO224563	LUSC	ICGC	PPKY	ITCH	9:12	Mutation altering degron motif	0.7031
p.E21K	DO50284	SKCM	ICGC	PPKY	ITCH	9:12	Mutation rewiring degron network	0.0833
p.V4I	DO42280	UCEC	ICGC	PPKY	ITCH	9:12	Mutation rewiring degron network	0.1944
p.V4I	DO42665	UCEC	ICGC	PPKY	ITCH	9:12	Mutation rewiring degron network	0.1944
p.S17I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPKY	ITCH	9:12	Mutation rewiring degron network	0.1944
p.S17I	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	9:12	Mutation rewiring degron network	0.1944
p.E19K	SIDM01005	Acute Myeloid Leukemia	GDSC	PPKY	ITCH	9:12	Mutation rewiring degron network	0.1389
p.E19K	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	9:12	Mutation rewiring degron network	0.1389
p.T2A	SIDM00220	Ovarian Carcinoma	GDSC	PPKY	ITCH	9:12	Mutation substituting flanking lysine	0.25
p.E6K	ACH-000263	Leukemia	CCLE	PPKY	ITCH	9:12	Mutation rewiring degron network	0.25
p.E6K	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	9:12	Mutation rewiring degron network	0.25
p.K22N	ACH-000967	Colon/Colorectal Cancer	CCLE	PPKY	ITCH	9:12	Mutation substituting flanking lysine	0.1667
p.S20F	CAL-27	upper aerodigestive tract	COSMIC	PPKY	ITCH	9:12	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons