FUNCTION: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced ad...
FUNCTION: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. {ECO:0000269|PubMed:12676952, ECO:0000269|PubMed:12845325, ECO:0000269|PubMed:15569673}.
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GO - Biological processes (BP):
apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of protein localization to nucleus [GO:1900180]; signal transduction [GO:0007165]...
apoptotic process [GO:0006915]; negative regulation of cell population proliferation [GO:0008285]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of protein localization to nucleus [GO:1900180]; signal transduction [GO:0007165]
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GO - Molecular function (MF):
identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]...
identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]
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