DegronMD - Q8WWX8(SLC5A11)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P585T	TCGA-22-4593	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2778
p.S591C	TCGA-39-5034	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation altering degron motif	0.7541
p.V593I	TCGA-CJ-5679	KIRC	TCGA	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2778
p.V593I	TCGA-IR-A3L7	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2778
p.A597T	DO222884	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.1667
p.A597T	DO228138	PBCA	ICGC	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.1667
p.A597T	HCC1937	breast	COSMIC	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.1667
p.V588I	DO234183	ESAD	ICGC	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation altering degron motif	0.7076
p.A597S	DO229038	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.1667
p.C593W	DO45402	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2778
p.L586M	DO26466	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.3056
p.V594L	DO218900	SKCA	ICGC	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.25
p.G583E	SIDM00007	Other Solid Cancers	GDSC	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2222
p.G583E	ACH-001550	Skin Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2222
p.G583E	MCC13	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.2222
p.I592T	COR-L88	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	587:591	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons