DegronMD - Q8WX39(LCN9)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V111I	TCGA-68-7756	LUSC	TCGA	DYR	CBL_MET	115:117	Mutation rewiring degron network	0.2222
p.V111I	TCGA-AZ-6608	COAD	TCGA	DYR	CBL_MET	115:117	Mutation rewiring degron network	0.2222
p.V111I	DO7954	COAD	ICGC	DYR	CBL_MET	115:117	Mutation rewiring degron network	0.2222
p.V111I	DO26474	LUSC	ICGC	DYR	CBL_MET	115:117	Mutation rewiring degron network	0.2222
p.V111I	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	115:117	Mutation rewiring degron network	0.2222
p.S112L	TCGA-AX-A0J0	UCEC	TCGA	DYR	CBL_MET	115:117	Mutation rewiring degron network	0.25
p.S112L	DO41133	UCEC	ICGC	DYR	CBL_MET	115:117	Mutation rewiring degron network	0.25
p.Q106H	DO225209	BRCA	ICGC	DYR	CBL_MET	115:117	Mutation rewiring degron network	0.0833
p.G105V	DO228974	LICA	ICGC	DYR	CBL_MET	115:117	Mutation rewiring degron network	0.0556

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons