DegronMD - Q8WXI9(GATAD2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M142L	TCGA-A6-3807	COAD	TCGA	PRSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2778
p.M142L	DO9034	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2778
p.R141K	TCGA-AO-A0J9	BRCA	TCGA	PRSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.R141K	DO3221	BRCA	ICGC	PRSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.R310C	TCGA-AX-A2HD	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.R310C	DO23108	LINC	ICGC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.R310C	DO45041	LINC	ICGC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.R310C	DO42608	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.N131S	TCGA-BT-A20O	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.N131S	DO460	BLCA	ICGC	PRSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.N131S	DO225215	BRCA	ICGC	PRSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.N131S	DO227836	BRCA	ICGC	PRSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.S304Y	TCGA-EY-A1GI	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.712
p.S304Y	TCGA-F5-6814	READ	TCGA	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.712
p.S304Y	DO222884	COCA	ICGC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.712
p.S304Y	DO36556	READ	ICGC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.712
p.S304Y	DO41211	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation altering degron motif	0.712
p.E144Q	DO223012	ESCA	ICGC	PRSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2222
p.R310H	DO233199	GACA	ICGC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.R310H	SIDM00781	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.R310H	SIDM00780	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.R310H	ACH-000967	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.R310H	ACH-001199	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.R310H	SNU-C2B	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667
p.L146F	DO228376	MALY	ICGC	PRSSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.S139G	SIDM00043	Head and Neck Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.6993
p.Q309K	SIDM00193	Colorectal Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.Q309K	ACH-000991	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.Q309K	SNU-81	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1944
p.Q293K	SNU-81	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1389
p.R294H	SNU-C2B	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	300:304	Mutation rewiring degron network	0.1667

Kaplan plot for GATAD2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GATAD2B

UniProt ID: Q8WXI9

Entrez ID: 57459

Protein name: Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GATAD2B in