DegronMD - Q8WY36(BBX)

FUNCTION: Transcription factor that is necessary for cell cycle progression from G1 to S phase. {ECO:0000269|PubMed:11680820}.

GO - Biological processes (BP): bone development [GO:0060348]; regulation of transcription by RNA polymerase II [GO:0006357]

GO - Molecular function (MF): DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific double-stranded DNA binding [GO:1990837]

GO - Cellular component (CC): chromatin [GO:0000785]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M515R	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.8632
p.E511G	ACH-000985	Colon/Colorectal Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.7199
p.E511G	LS-411N	large intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.7199
p.R512C	TCGA-59-2349	OV	TCGA	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.719
p.R512C	DO28621	OV	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.719
p.R512C	SIDM00392	Melanoma	GDSC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.719
p.R512C	ACH-000810	Skin Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.719
p.R512C	SK-MEL-30	skin	COSMIC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.719
p.P222Q	TCGA-FS-A1Z0	SKCM	TCGA	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation altering degron motif	0.7035
p.P222Q	DO37431	SKCM	ICGC	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation altering degron motif	0.7035
p.G506E	DO22295	LGG	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation blocking phosphorylation signal	0.6389
p.G506E	ACH-000786	Lymphoma	CCLE	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation blocking phosphorylation signal	0.6389
p.Q502L	ACH-000786	Lymphoma	CCLE	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation blocking ubiquitination signal	0.5278
p.S516C	TCGA-86-8585	LUAD	TCGA	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.3056
p.S516C	DO24850	LUAD	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.3056
p.S516N	TCGA-86-8585	LUAD	TCGA	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.3056
p.S516N	DO24850	LUAD	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.3056
p.S805F	TCGA-A5-A2K5	UCEC	TCGA	IFNTPEPT	DEG_SCF_FBW7_1	806:813	Mutation rewiring degron network	0.3056
p.A218V	TCGA-B5-A11E	UCEC	TCGA	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.3056
p.A218V	DO41644	UCEC	ICGC	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 54 entries

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Kaplan plot for BBX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BBX

UniProt ID: Q8WY36

Entrez ID: 56987

Protein name: HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BBX in