DegronMD - Q8WY36(BBX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R512C	TCGA-59-2349	OV	TCGA	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.719
p.R512C	DO28621	OV	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.719
p.R512C	SIDM00392	Melanoma	GDSC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.719
p.R512C	ACH-000810	Skin Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.719
p.R512C	SK-MEL-30	skin	COSMIC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.719
p.S516C	TCGA-86-8585	LUAD	TCGA	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.3056
p.S516C	DO24850	LUAD	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.3056
p.S516N	TCGA-86-8585	LUAD	TCGA	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.3056
p.S516N	DO24850	LUAD	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.3056
p.E817K	TCGA-91-8497	LUAD	TCGA	IFNTPEPT	DEG_SCF_FBW7_1	806:813	Mutation rewiring degron network	0.2222
p.S805F	TCGA-A5-A2K5	UCEC	TCGA	IFNTPEPT	DEG_SCF_FBW7_1	806:813	Mutation rewiring degron network	0.3056
p.A218V	TCGA-B5-A11E	UCEC	TCGA	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.3056
p.A218V	DO41644	UCEC	ICGC	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.3056
p.E501Q	TCGA-BA-4077	HNSC	TCGA	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0556
p.E501Q	DO1146	BRCA	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0556
p.E501Q	DO15647	HNSC	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.0556
p.D505H	TCGA-BA-4077	HNSC	TCGA	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1667
p.D505H	DO15647	HNSC	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1667
p.L522F	TCGA-BA-4077	HNSC	TCGA	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1389
p.L522F	DO15647	HNSC	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1389
p.V797A	TCGA-BS-A0UF	UCEC	TCGA	IFNTPEPT	DEG_SCF_FBW7_1	806:813	Mutation rewiring degron network	0.0833
p.H798R	TCGA-DI-A1BU	UCEC	TCGA	IFNTPEPT	DEG_SCF_FBW7_1	806:813	Mutation rewiring degron network	0.1111
p.D232G	TCGA-EY-A548	UCEC	TCGA	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.1389
p.D232G	DO48173	UCEC	ICGC	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.1389
p.P507S	TCGA-FR-A726	SKCM	TCGA	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.2222
p.P507S	DO48665	SKCM	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.2222
p.P222Q	TCGA-FS-A1Z0	SKCM	TCGA	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation altering degron motif	0.7035
p.P222Q	DO37431	SKCM	ICGC	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation altering degron motif	0.7035
p.G215V	TCGA-FS-A1ZM	SKCM	TCGA	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.2222
p.G215V	DO37731	SKCM	ICGC	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.2222
p.G506E	DO22295	LGG	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation blocking phosphorylation signal	0.6389
p.G506E	ACH-000786	Lymphoma	CCLE	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation blocking phosphorylation signal	0.6389
p.V233F	DO229015	LICA	ICGC	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.1111
p.Y507C	DO44714	LICA	ICGC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.2222
p.K799R	DO50820	LIRI	ICGC	IFNTPEPT	DEG_SCF_FBW7_1	806:813	Mutation substituting flanking lysine	0.25
p.K799N	DO26665	LUSC	ICGC	IFNTPEPT	DEG_SCF_FBW7_1	806:813	Mutation substituting flanking lysine	0.25
p.K525N	SIDM02039	Colorectal Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation substituting flanking lysine	0.1667
p.M210V	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.0833
p.M210V	ACH-000605	Esophageal Cancer	CCLE	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.0833
p.M210V	TE-6	oesophagus	COSMIC	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.0833
p.R508C	SIDM00290	Gastric Carcinoma	GDSC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.25
p.R508C	ACH-000847	Gastric Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.25
p.R508C	HGC-27	stomach	COSMIC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.25
p.Q502L	ACH-000786	Lymphoma	CCLE	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation blocking ubiquitination signal	0.5278
p.S209C	ACH-000844	Lung Cancer	CCLE	LGTPEVS	DEG_SCF_FBW7_1	219:225	Mutation rewiring degron network	0.0556
p.E511G	ACH-000985	Colon/Colorectal Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.7199
p.E511G	LS-411N	large intestine	COSMIC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.7199
p.A505V	ACH-001517	Endometrial/Uterine Cancer	CCLE	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1667
p.A505V	HEC-1	endometrium	COSMIC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation rewiring degron network	0.1667
p.N821D	ACH-002165	Skin Cancer	CCLE	IFNTPEPT	DEG_SCF_FBW7_1	806:813	Mutation rewiring degron network	0.1111
p.N821D	MZ2-MEL	skin	COSMIC	IFNTPEPT	DEG_SCF_FBW7_1	806:813	Mutation rewiring degron network	0.1111
p.D801E	KCL-22	haematopoietic and lymphoid tissue	COSMIC	IFNTPEPT	DEG_SCF_FBW7_1	806:813	Mutation substituting flanking lysine	0.3056
p.D821E	KCL-22	haematopoietic and lymphoid tissue	COSMIC	IFNTPEPT	DEG_SCF_FBW7_1	806:813	Mutation rewiring degron network	0.1111
p.M515R	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VRTSS	DEG_SPOP_SBC_1	511:515	Mutation altering degron motif	0.8632

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BBX

UniProt ID: Q8WY36

Entrez ID: 56987

Protein name: HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BBX in