DegronMD - Q92581(SLC9A6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A601T	TCGA-A5-A1OF	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	611:615	Mutation blocking phosphorylation signal	0.5
p.A601T	TCGA-AX-A1CE	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	611:615	Mutation blocking phosphorylation signal	0.5
p.A601T	TCGA-EY-A215	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	611:615	Mutation blocking phosphorylation signal	0.5
p.L625I	TCGA-AP-A1E0	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	611:615	Mutation blocking phosphorylation signal	0.5
p.L623I	TCGA-BS-A0UF	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.1111
p.D622Y	TCGA-EE-A183	SKCM	TCGA	PATSS	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.1389
p.E611K	TCGA-FI-A2D5	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.7022
p.G622E	DO569	BLCA	ICGC	PATSS	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.1389
p.N608Y	DO1271	BRCA	ICGC	PATSS	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.25
p.S615I	DO229024	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.7341
p.A612D	DO28923	OV	ICGC	PATSS	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.6682
p.S625Y	DO41572	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	611:615	Mutation blocking phosphorylation signal	0.5
p.E611Q	SIDM00270	Head and Neck Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.6744
p.E611Q	ACH-002294	Head and Neck Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.6744
p.E611Q	PCI-15A	upper aerodigestive tract	COSMIC	PATSS	DEG_SPOP_SBC_1	611:615	Mutation altering degron motif	0.6744
p.P605L	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	611:615	Mutation rewiring degron network	0.1667

Kaplan plot for SLC9A6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC9A6

UniProt ID: Q92581

Entrez ID: 10479

Protein name: Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC9A6 in