DegronMD - Q92622(RUBCN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E347K	SIDM00672	Hepatocellular Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00484	Thyroid Gland Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00773	Non-Cancerous	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00969	Ovarian Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM01117	Small Cell Lung Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00529	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00694	Other Solid Cancers	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00879	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00346	Chronic Myelogenous Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00493	Other Solid Cancers	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM01147	Gastric Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM01133	Other Solid Cancers	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00068	Colorectal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00431	T-Lymphoblastic Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00479	Esophageal Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00774	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00257	Neuroblastoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00808	Burkitt's Lymphoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM00628	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM01318	Hepatocellular Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.E347K	SIDM01254	Burkitt's Lymphoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.591
p.S350N	SIDM01245	T-Lymphoblastic Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.7069
p.S350N	SIDM00878	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.7069
p.S350N	SIDM00920	Breast Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.7069
p.S350N	SIDM00991	T-Lymphoblastic Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.7069
p.S355F	SIDM01175	Other Sarcomas	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.S355F	SIDM01059	Melanoma	GDSC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.S355F	SW684	soft tissue	COSMIC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.S355F	IPC-298	skin	COSMIC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.S339N	NCI-H1155	lung	COSMIC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1389
p.G340E	SKN-3	upper aerodigestive tract	COSMIC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1667
p.G340E	LoVo	large intestine	COSMIC	AESSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1667

Kaplan plot for RUBCN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RUBCN

UniProt ID: Q92622

Entrez ID: 9711

Protein name: Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RUBCN in