DegronMD - Q92754(TFAP2C)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A68T	TCGA-AA-3663	COAD	TCGA	PPPY	ITCH	56:59	Mutation rewiring degron network	0.0833
p.A68T	TCGA-AA-3663	COAD	TCGA	PPPY	ITCH	61:64	Mutation rewiring degron network	0.2222
p.A68T	TCGA-OR-A5LL	ACC	TCGA	PPPY	ITCH	56:59	Mutation rewiring degron network	0.0833
p.A68T	TCGA-OR-A5LL	ACC	TCGA	PPPY	ITCH	61:64	Mutation rewiring degron network	0.2222
p.A68T	DO9346	COAD	ICGC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.0833
p.A68T	DO9346	COAD	ICGC	PPPY	ITCH	61:64	Mutation rewiring degron network	0.2222
p.E53K	TCGA-AP-A1DV	UCEC	TCGA	PPPY	ITCH	56:59	Mutation rewiring degron network	0.25
p.E53K	TCGA-AP-A1DV	UCEC	TCGA	PPPY	ITCH	61:64	Mutation rewiring degron network	0.1111
p.E53K	DO230313	COCA	ICGC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.25
p.E53K	DO230313	COCA	ICGC	PPPY	ITCH	61:64	Mutation rewiring degron network	0.1111
p.E53K	DO43186	UCEC	ICGC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.25
p.E53K	DO43186	UCEC	ICGC	PPPY	ITCH	61:64	Mutation rewiring degron network	0.1111
p.S72L	TCGA-D5-6928	COAD	TCGA	PPPY	ITCH	61:64	Mutation rewiring degron network	0.1111
p.P56L	TCGA-DM-A1D8	COAD	TCGA	PPPY	ITCH	56:59	Mutation altering degron motif	0.7582
p.P61S	TCGA-FR-A726	SKCM	TCGA	PPPY	ITCH	61:64	Mutation altering degron motif	0.6752
p.P61S	DO48665	SKCM	ICGC	PPPY	ITCH	61:64	Mutation altering degron motif	0.6752
p.S47F	TCGA-FR-A8YC	SKCM	TCGA	PPPY	ITCH	56:59	Mutation rewiring degron network	0.0833
p.S47F	DO50301	SKCM	ICGC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.0833
p.E53D	TCGA-P3-A5QE	HNSC	TCGA	PPPY	ITCH	56:59	Mutation rewiring degron network	0.25
p.E53D	TCGA-P3-A5QE	HNSC	TCGA	PPPY	ITCH	61:64	Mutation rewiring degron network	0.1111
p.E53D	DO44418	HNSC	ICGC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.25
p.E53D	DO44418	HNSC	ICGC	PPPY	ITCH	61:64	Mutation rewiring degron network	0.1111
p.M49I	DO1301	BRCA	ICGC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.1389
p.M49I	DO229015	LICA	ICGC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.1389
p.V48I	DO234445	ESAD	ICGC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.1111
p.C56F	DO229018	LICA	ICGC	PPPY	ITCH	56:59	Mutation altering degron motif	0.7108
p.Q65K	DO51505	PACA	ICGC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.1667
p.Q65K	DO51505	PACA	ICGC	PPPY	ITCH	61:64	Mutation rewiring degron network	0.3056
p.G60E	DO37454	SKCM	ICGC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.3056
p.G60E	DO37454	SKCM	ICGC	PPPY	ITCH	61:64	Mutation rewiring degron network	0.3056
p.P59S	DO51276	SKCM	ICGC	PPPY	ITCH	56:59	Mutation altering degron motif	0.6752
p.S66R	DO229259	THCA	ICGC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.1389
p.S66R	DO229259	THCA	ICGC	PPPY	ITCH	61:64	Mutation rewiring degron network	0.2778
p.Y69H	SIDM01090	Colorectal Carcinoma	GDSC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.0556
p.Y69H	SIDM01090	Colorectal Carcinoma	GDSC	PPPY	ITCH	61:64	Mutation rewiring degron network	0.1944
p.Y69H	ACH-000943	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	56:59	Mutation rewiring degron network	0.0556
p.Y69H	ACH-000943	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	61:64	Mutation rewiring degron network	0.1944
p.Y69H	RKO	large intestine	COSMIC	PPPY	ITCH	56:59	Mutation rewiring degron network	0.0556
p.Y69H	RKO	large intestine	COSMIC	PPPY	ITCH	61:64	Mutation rewiring degron network	0.1944

Kaplan plot for TFAP2C in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TFAP2C

UniProt ID: Q92754

Entrez ID: 7022

Protein name: Transcription factor AP-2 gamma (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TFAP2C in