DegronMD - Q92800(EZH1)

EZH1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A397T	TCGA-AX-A1CE	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7139
p.S405F	TCGA-FR-A3YO	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.Q402H	DO51925	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.3056
p.D389Y	DO8216	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1111
p.H387R	DO233942	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0556
p.S394R	DO228976	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.25
p.K407M	DO26761	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1667
p.P388S	DO222843	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation blocking phosphorylation signal	0.5278
p.F404V	DO229257	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.25
p.D391E	ACH-000710	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1667
p.C395Y	ACH-002287	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2778
p.C395Y	NCI-H630	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2778
p.Q397R	MFE-319	endometrium	COSMIC	ASSSS	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7329

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*NOTE: the Kaplan plots were collected from OncoLnc