DegronMD - Q92896(GLG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A941S	TCGA-12-0829	GBM	TCGA	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1111
p.A941S	DO11166	GBM	ICGC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1111
p.R924C	TCGA-B5-A1MR	UCEC	TCGA	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1389
p.R924C	TCGA-WS-AB45	COAD	TCGA	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1389
p.R924C	DO51734	COAD	ICGC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1389
p.R924C	DO41758	UCEC	ICGC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1389
p.R924H	TCGA-DF-A2KU	UCEC	TCGA	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1389
p.R924H	DO233652	GACA	ICGC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1389
p.R924H	DO223286	UCEC	ICGC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1389
p.I921M	TCGA-EC-A1QX	UCEC	TCGA	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.0556
p.I921M	DO42592	UCEC	ICGC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.0556
p.I921M	SIDM00516	Melanoma	GDSC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.0556
p.I921M	MZ7-mel	skin	COSMIC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.0556
p.I226V	TCGA-F5-6814	READ	TCGA	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.2222
p.I226V	DO36556	READ	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.2222
p.A225T	DO230311	COCA	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.1944
p.K943E	DO227657	COCA	ICGC	DYR	CBL_MET	931:933	Mutation substituting flanking lysine	0.1667
p.P936S	DO227984	COCA	ICGC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.25
p.R924S	DO229032	LICA	ICGC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1389
p.T221N	DO229045	LICA	ICGC	DYR	CBL_MET	230:232	Mutation rewiring degron network	0.0833
p.T930K	DO229009	LICA	ICGC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.3056
p.K923R	SIDM00789	Colorectal Carcinoma	GDSC	DYR	CBL_MET	931:933	Mutation substituting flanking lysine	0.2222
p.K923R	ACH-001091	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	931:933	Mutation substituting flanking lysine	0.2222
p.K923R	HCT-15	large intestine	COSMIC	DYR	CBL_MET	931:933	Mutation substituting flanking lysine	0.2222
p.R933C	SIDM00007	Other Solid Cancers	GDSC	DYR	CBL_MET	931:933	Mutation altering degron motif	0.8301
p.R933C	MCC13	skin	COSMIC	DYR	CBL_MET	931:933	Mutation altering degron motif	0.8301
p.Q925H	SIDM00211	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1667
p.Q925H	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1667
p.Q925L	SIDM00211	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1667
p.Q925L	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.1667
p.T922A	SIDM00333	Endometrial Carcinoma	GDSC	DYR	CBL_MET	931:933	Mutation blocking phosphorylation signal	0.5278
p.T922A	MFE-319	endometrium	COSMIC	DYR	CBL_MET	931:933	Mutation blocking phosphorylation signal	0.5278
p.M937T	SIDM01397	Melanoma	GDSC	DYR	CBL_MET	931:933	Mutation rewiring degron network	0.2222
p.R922H	ACH-000930	Breast Cancer	CCLE	DYR	CBL_MET	931:933	Mutation blocking phosphorylation signal	0.5278
p.R922H	HCC1569	breast	COSMIC	DYR	CBL_MET	931:933	Mutation blocking phosphorylation signal	0.5278
p.R922C	ACH-001550	Skin Cancer	CCLE	DYR	CBL_MET	931:933	Mutation blocking phosphorylation signal	0.5278
p.R922C	MCC13	skin	COSMIC	DYR	CBL_MET	931:933	Mutation blocking phosphorylation signal	0.5278
p.R933H	HCC1569	breast	COSMIC	DYR	CBL_MET	931:933	Mutation altering degron motif	0.8244

Kaplan plot for GLG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GLG1

UniProt ID: Q92896

Entrez ID: 2734

Protein name: Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GLG1 in