DegronMD - Q92934(BAD)

GO - Biological processes (BP): activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; ADP metabolic process [GO:0046031]; apoptotic process [GO:0006915]; ATP metabolic process [GO:0046034]; cellular response to chromate [GO:0071247]; cellular response to hypoxia [GO:0071456]; cellular response to lipid [GO:0071396]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cerebral cortex development [GO:0021987]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glucose catabolic process [GO:0006007]; glucose homeostasis [GO:0042593]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; pore complex assembly [GO:0046931]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of glucokinase activity [GO:0033133]; positive regulation of granulosa cell apoptotic process [GO:1904710]; positive regulation of insulin secretion [GO:0032024]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902220]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of neuron death [GO:1901216]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of type B pancreatic cell development [GO:2000078]; regulation of mitochondrial membrane permeability [GO:0046902]; release of cytochrome c from mitochondria [GO:0001836]; response to amino acid [GO:0043200]; response to benzene [GO:1901423]; response to calcium ion [GO:0051592]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to oleic acid [GO:0034201]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to xenobiotic stimulus [GO:0009410]; spermatogenesis [GO:0007283]; type B pancreatic cell proliferation [GO:0044342] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G62E	TCGA-IB-7651	PAAD	TCGA	PTSSS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.25
p.G62E	DO46657	PAAD	ICGC	PTSSS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.25
p.S49N	TCGA-W5-AA2W	CHOL	TCGA	PTSSS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.1667
p.H61N	DO229036	LICA	ICGC	PTSSS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.2778
p.G64W	DO37405	SKCM	ICGC	PTSSS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.1944
p.T65I	ACH-000981	Leukemia	CCLE	PTSSS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.1667
p.T65I	DND-41	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	55:59	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAD

UniProt ID: Q92934

Entrez ID: 572

Protein name: Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BAD in