DegronMD - Q96A35(MRPL24)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R105W	TCGA-B9-A44B	KIRP	TCGA	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8634
p.R105W	DO44496	KIRP	ICGC	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8634
p.R105W	SIDM00492	Glioblastoma	GDSC	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8634
p.R105W	SIDM01578	Bladder Carcinoma	GDSC	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8634
p.R105W	ACH-000269	Brain Cancer	CCLE	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8634
p.R105W	ACH-000862	Bladder Cancer	CCLE	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8634
p.R105W	ACH-002042	Thyroid Cancer	CCLE	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8634
p.R105W	AM-38	central nervous system	COSMIC	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8634
p.P110T	TCGA-EB-A24C	SKCM	TCGA	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.1944
p.P110T	DO37438	SKCM	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.1944
p.R105L	TCGA-EE-A2ML	SKCM	TCGA	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8428
p.R105L	DO37408	SKCM	ICGC	DYR	CBL_MET	103:105	Mutation altering degron motif	0.8428
p.T93I	TCGA-MX-A5UJ	STAD	TCGA	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.0556
p.T93I	DO48547	STAD	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.0556
p.G22R	DO222404	BTCA	ICGC	PPHY	ITCH	16:19	Mutation rewiring degron network	0.25
p.M108I	DO228638	GACA	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.25
p.H94R	DO228908	LICA	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.0833
p.P16T	DO229025	LICA	ICGC	PPHY	ITCH	16:19	Mutation altering degron motif	0.7031
p.P114S	DO220902	MELA	ICGC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.0833
p.V13I	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPHY	ITCH	16:19	Mutation rewiring degron network	0.25
p.V13I	SIDM01160	Bladder Carcinoma	GDSC	PPHY	ITCH	16:19	Mutation rewiring degron network	0.25
p.V13I	SIDM01193	Glioma	GDSC	PPHY	ITCH	16:19	Mutation rewiring degron network	0.25
p.V13I	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPHY	ITCH	16:19	Mutation rewiring degron network	0.25
p.M102I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.3056
p.M102I	ACH-000920	Leukemia	CCLE	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.3056
p.M102I	CML-T1	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	103:105	Mutation rewiring degron network	0.3056

Kaplan plot for MRPL24 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MRPL24

UniProt ID: Q96A35

Entrez ID: 79590

Protein name: 39S ribosomal protein L24, mitochondrial (L24mt) (MRP-L24) (Mitochondrial large ribosomal subunit protein uL24m)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MRPL24 in