DegronMD - Q96A65(EXOC4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D243N	TCGA-AG-A014	READ	TCGA	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.D243N	DO36860	READ	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.E242Q	DO51863	BLCA	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1111
p.E257D	DO52642	BOCA	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.25
p.T261A	DO225346	BRCA	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.K251R	DO22135	LGG	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7237
p.H246P	DO228957	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2222
p.D243Y	DO229029	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.S261F	DO222390	MELA	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.S261F	DO37996	SKCM	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.D253G	DO27991	OV	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7198
p.V262I	DO31270	OV	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1111
p.L243R	DO41542	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.G251R	SIDM00660	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6457
p.G251R	ACH-000985	Colon/Colorectal Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6457
p.G251R	LS-411N	large intestine	COSMIC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6457
p.N259H	SIDM00487	Colorectal Carcinoma	GDSC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.N259H	ACH-000963	Colon/Colorectal Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.N259H	CCK-81	large intestine	COSMIC	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.L242F	ACH-001857	Bile Duct Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1111

Kaplan plot for EXOC4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EXOC4

UniProt ID: Q96A65

Entrez ID: 60412

Protein name: Exocyst complex component 4 (Exocyst complex component Sec8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EXOC4 in