DegronMD - Q96BD5(PHF21A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G646D	TCGA-AX-A06F	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.0833
p.Y434C	TCGA-B5-A3FA	UCEC	TCGA	PPKY	ITCH	431:434	Mutation altering degron motif	0.7087
p.R430H	TCGA-CV-7104	HNSC	TCGA	PPKY	ITCH	431:434	Mutation rewiring degron network	0.3056
p.D648N	TCGA-K4-A6MB	BLCA	TCGA	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1389
p.L443F	TCGA-Z2-A8RT	SKCM	TCGA	PPKY	ITCH	431:434	Mutation rewiring degron network	0.0833
p.D649N	DO44077	BLCA	ICGC	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1667
p.R431H	DO14798	HNSC	ICGC	PPKY	ITCH	431:434	Mutation altering degron motif	0.8244
p.T660K	DO229006	LICA	ICGC	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.3056
p.P665T	DO50935	LICA	ICGC	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1667
p.S659F	DO222696	MELA	ICGC	AATST	DEG_SPOP_SBC_1	655:659	Mutation altering degron motif	0.7982
p.E432D	DO37778	SKCM	ICGC	PPKY	ITCH	431:434	Mutation altering degron motif	0.6758
p.L444F	DO51301	SKCM	ICGC	PPKY	ITCH	431:434	Mutation blocking phosphorylation signal	0.5
p.G647D	DO41752	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1111
p.Y435C	DO52402	UCEC	ICGC	PPKY	ITCH	431:434	Mutation rewiring degron network	0.3056
p.P652T	SIDM00263	Ewing's Sarcoma	GDSC	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.25
p.P652T	ACH-002106	Bone Cancer	CCLE	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.25
p.P652T	ES5	bone	COSMIC	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.25
p.H422Y	SIDM00217	Colorectal Carcinoma	GDSC	PPKY	ITCH	431:434	Mutation rewiring degron network	0.0833
p.H422Y	ACH-000999	Colon/Colorectal Cancer	CCLE	PPKY	ITCH	431:434	Mutation rewiring degron network	0.0833
p.H422Y	SNU-1040	large intestine	COSMIC	PPKY	ITCH	431:434	Mutation rewiring degron network	0.0833
p.K433E	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPKY	ITCH	431:434	Mutation altering degron motif	0.591
p.K433E	ACH-001737	Leukemia	CCLE	PPKY	ITCH	431:434	Mutation altering degron motif	0.591
p.K433E	ACH-002222	Leukemia	CCLE	PPKY	ITCH	431:434	Mutation altering degron motif	0.591
p.K433E	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	431:434	Mutation altering degron motif	0.591
p.T650I	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1944
p.T650I	SIDM01490	Small Cell Lung Carcinoma	GDSC	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1944
p.T650I	RL	haematopoietic and lymphoid tissue	COSMIC	AATST	DEG_SPOP_SBC_1	655:659	Mutation rewiring degron network	0.1944
p.H423Y	SNU-1040	large intestine	COSMIC	PPKY	ITCH	431:434	Mutation rewiring degron network	0.1111

Kaplan plot for PHF21A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHF21A

UniProt ID: Q96BD5

Entrez ID: 51317

Protein name: PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHF21A in