DegronMD - Q96C57(CUSTOS)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R159W	TCGA-63-A5MM	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.1111
p.R142C	TCGA-FS-A1ZN	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.1944
p.S138F	TCGA-QQ-A8VG	SARC	TCGA	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation blocking phosphorylation signal	0.5278
p.R152Q	DO7784	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.3056
p.K144T	DO233259	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation substituting flanking lysine	0.3611
p.K147N	DO49051	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation altering degron motif	0.6918
p.A160D	DO229029	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.0833
p.L152V	DO26749	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.3056
p.S138C	DO26632	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation blocking phosphorylation signal	0.5278
p.R150G	DO43362	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation altering degron motif	0.7568
p.E149D	SIDM00217	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation altering degron motif	0.6758
p.C161Y	ACH-002113	Bone Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	147:151	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons