DegronMD - Q96CN4(EVI5L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S72G	TCGA-CM-4743	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.8104
p.S72G	DO8103	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.8104
p.S68L	TCGA-DA-A1HV	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.2778
p.S68L	DO37659	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.2778
p.S80I	DO228974	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1667
p.R62L	DO229031	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1111
p.G60V	DO229009	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556
p.S74L	DO220886	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.7667
p.S74L	SIDM02072	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.7667
p.L79P	DO229257	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.1944
p.S73F	SIDM00807	Bladder Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.9093
p.S73F	ACH-000905	Bladder Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.9093
p.S73F	5637	urinary tract	COSMIC	VSSSS	DEG_SPOP_SBC_1	70:74	Mutation altering degron motif	0.9093

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons