DegronMD - Q96CN9(GCC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G151V	TCGA-60-2720	LUSC	TCGA	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1389
p.G151V	TCGA-D3-A8GK	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1389
p.G151V	DO26587	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1389
p.G151V	DO50286	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1389
p.G139S	TCGA-78-7150	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.3056
p.G139S	DO24411	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.3056
p.G139S	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.3056
p.S144R	TCGA-A5-A0G2	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7427
p.S144R	DO41235	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7427
p.S144R	ACH-001669	Leukemia	CCLE	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7427
p.S144R	ACH-002238	Leukemia	CCLE	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7427
p.S144R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation altering degron motif	0.7427
p.E137D	TCGA-AB-2936	LAML	TCGA	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.25
p.E137D	TCGA-KM-8438	KICH	TCGA	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.25
p.E137D	DO220355	KICH	ICGC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.25
p.E137D	DO21349	LAML	ICGC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.25
p.G152R	TCGA-D3-A8GK	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1111
p.G152R	DO50286	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.1111
p.S136P	TCGA-FI-A2D5	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.2222
p.S136P	DO41331	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.2222
p.E131K	SIDM00290	Gastric Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.0833
p.E131K	ACH-000847	Gastric Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.0833
p.E131K	HGC-27	stomach	COSMIC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.0833
p.E137K	SIDM01619	Endometrial Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.25
p.E137K	ACH-000984	Endometrial/Uterine Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	140:144	Mutation rewiring degron network	0.25

Kaplan plot for GCC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GCC1

UniProt ID: Q96CN9

Entrez ID: 79571

Protein name: GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GCC1 in