DegronMD - Q96CS7(PLEKHB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A134T	TCGA-63-A5MM	LUSC	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.2778
p.A134T	DO219153	LUSC	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.2778
p.P138L	TCGA-AJ-A3BH	UCEC	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1667
p.P138L	DO41638	UCEC	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1667
p.P130S	TCGA-BF-A5ES	SKCM	TCGA	PPPY	ITCH	129:132	Mutation altering degron motif	0.6752
p.P130S	TCGA-CC-A9FW	LIHC	TCGA	PPPY	ITCH	129:132	Mutation altering degron motif	0.6752
p.P130S	DO219557	LIHC	ICGC	PPPY	ITCH	129:132	Mutation altering degron motif	0.6752
p.P130S	DO219456	SKCM	ICGC	PPPY	ITCH	129:132	Mutation altering degron motif	0.6752
p.V142A	TCGA-DI-A1BU	UCEC	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.V142I	TCGA-WE-AAA0	SKCM	TCGA	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.A119V	DO233903	GACA	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0556
p.E141D	DO229031	LICA	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0833
p.V122L	DO49875	LUAD	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1389
p.G121V	DO26587	LUSC	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1111
p.T128I	DO219122	LUSC	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.3056
p.P127L	DO37471	SKCM	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.2778
p.P123L	DO50291	SKCM	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1667
p.Y120C	DO229264	THCA	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.0833
p.V122M	DO41422	UCEC	ICGC	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1389
p.P140L	ACH-001510	Head and Neck Cancer	CCLE	PPPY	ITCH	129:132	Mutation rewiring degron network	0.1111

Kaplan plot for PLEKHB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHB2

UniProt ID: Q96CS7

Entrez ID: 55041

Protein name: Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHB2 in