DegronMD - Q96DD7(SHISA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P190L	TCGA-A5-A0G2	UCEC	TCGA	PPPY	ITCH	184:187	Mutation rewiring degron network	0.25
p.P190L	DO41235	UCEC	ICGC	PPPY	ITCH	184:187	Mutation rewiring degron network	0.25
p.P186S	TCGA-D3-A8GP	SKCM	TCGA	PPPY	ITCH	184:187	Mutation altering degron motif	0.5641
p.P186S	DO51244	SKCM	ICGC	PPPY	ITCH	184:187	Mutation altering degron motif	0.5641
p.P170S	TCGA-EE-A3AG	SKCM	TCGA	PPVY	ITCH	176:179	Mutation rewiring degron network	0.1667
p.P170S	DO37471	SKCM	ICGC	PPVY	ITCH	176:179	Mutation rewiring degron network	0.1667
p.P195L	TCGA-QG-A5YV	COAD	TCGA	PPPY	ITCH	184:187	Mutation rewiring degron network	0.1111
p.P195L	DO44088	COAD	ICGC	PPPY	ITCH	184:187	Mutation rewiring degron network	0.1111
p.P195L	SIDM01378	Ovarian Carcinoma	GDSC	PPPY	ITCH	184:187	Mutation rewiring degron network	0.1111
p.P195L	ACH-000646	Ovarian Cancer	CCLE	PPPY	ITCH	184:187	Mutation rewiring degron network	0.1111
p.P177L	SIDM00103	Mesothelioma	GDSC	PPVY	ITCH	176:179	Mutation altering degron motif	0.7582

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons