FUNCTION: Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated d...
FUNCTION: Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758}.
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GO - Biological processes (BP):
mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of cell growth [GO:0030307]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]...
mitotic G2/M transition checkpoint [GO:0044818]; positive regulation of cell growth [GO:0030307]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]
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GO - Molecular function (MF):
protein serine/threonine phosphatase inhibitor activity [GO:0004865]...
protein serine/threonine phosphatase inhibitor activity [GO:0004865]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; nucleus [GO:0005634]
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