DegronMD - Q96FV0(LRRC46)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A300T	TCGA-DU-6392	LGG	TCGA	APSTT	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1111
p.A300T	DO22237	LGG	ICGC	APSTT	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1111
p.A300S	DO232941	PEME	ICGC	APSTT	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1111
p.T315M	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.25
p.T315M	ACH-000587	Lung Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.25
p.T315M	NCI-H1975	lung	COSMIC	APSTT	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.25
p.K302Q	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	308:312	Mutation substituting flanking lysine	0.2778
p.K302Q	ACH-000757	Lung Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	308:312	Mutation substituting flanking lysine	0.2778
p.K302Q	A427	lung	COSMIC	APSTT	DEG_SPOP_SBC_1	308:312	Mutation substituting flanking lysine	0.2778
p.T312A	SIDM01617	Endometrial Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7139
p.T312A	ACH-000994	Endometrial/Uterine Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7139

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons