DegronMD - Q96G42(KLHDC7B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P29S	TCGA-3B-A9HR	SARC	TCGA	PSTST	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6752
p.P29S	DO219932	SARC	ICGC	PSTST	DEG_SPOP_SBC_1	29:33	Mutation altering degron motif	0.6752
p.A109V	TCGA-AA-A01P	COAD	TCGA	AASSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.A109V	DO8642	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.A109T	TCGA-BK-A6W3	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.A109T	DO50076	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.Q125H	DO234239	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1944
p.R123H	DO14232	HNSC	ICGC	AASSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.25
p.H34Q	DO31729	OV	ICGC	PSTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.3056
p.A21T	DO218863	SKCA	ICGC	PSTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1111
p.L130P	DO229253	THCA	ICGC	AASSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.0556
p.V127L	ACH-000924	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.Q110E	ACH-000964	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1667
p.G40S	ACH-000995	Leukemia	CCLE	PSTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1389
p.G40S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PSTST	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons