DegronMD - Q96G74(OTUD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L484I	TCGA-2W-A8YY	CESC	TCGA	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.0833
p.A492V	TCGA-BR-6852	STAD	TCGA	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.3056
p.S489L	TCGA-CA-6717	COAD	TCGA	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation blocking phosphorylation signal	0.6667
p.G502E	TCGA-DA-A1IC	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.1944
p.T495I	TCGA-DK-A6B1	BLCA	TCGA	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation altering degron motif	0.7078
p.R505L	TCGA-EE-A2MP	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.1111
p.P487H	TCGA-EO-A3AV	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.1667
p.T490I	DO48534	BLCA	ICGC	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.25
p.S495L	DO222973	BTCA	ICGC	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation altering degron motif	0.7667
p.S495L	ACH-000562	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation altering degron motif	0.7667
p.S495L	HCC-78	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation altering degron motif	0.7667
p.S484L	DO8264	COAD	ICGC	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.0833
p.R500L	DO37818	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.25
p.G497E	DO37430	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation altering degron motif	0.7199
p.A487V	DO38202	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.1667
p.S500L	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.25
p.S500L	HCC-78	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation rewiring degron network	0.25
p.P486L	MCC13	skin	COSMIC	PGTSS	DEG_SPOP_SBC_1	493:497	Mutation substituting flanking lysine	0.25

Kaplan plot for OTUD5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTUD5

UniProt ID: Q96G74

Entrez ID: 55593

Protein name: OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTUD5 in