DegronMD - Q96GM5(SMARCD1)

FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342). Interacts with AKIRIN2 (By similarity). {ECO:0000250|UniProtKB:Q61466, ECO:0000269|PubMed:12917342, ECO:0000269|PubMed:14698202, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:8804307, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G82W	TCGA-46-3767	LUSC	TCGA	PPGY	ITCH	78:81	Mutation rewiring degron network	0.3056
p.G82W	DO26650	LUSC	ICGC	PPGY	ITCH	78:81	Mutation rewiring degron network	0.3056
p.R68L	TCGA-55-6970	LUAD	TCGA	PPGY	ITCH	78:81	Mutation rewiring degron network	0.0556
p.R68L	DO24421	LUAD	ICGC	PPGY	ITCH	78:81	Mutation rewiring degron network	0.0556
p.G82E	TCGA-B5-A3FA	UCEC	TCGA	PPGY	ITCH	78:81	Mutation rewiring degron network	0.3056
p.G82E	DO52402	UCEC	ICGC	PPGY	ITCH	78:81	Mutation rewiring degron network	0.3056
p.G82E	SIDM00150	Colorectal Carcinoma	GDSC	PPGY	ITCH	78:81	Mutation rewiring degron network	0.3056
p.G82E	ACH-000969	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	78:81	Mutation rewiring degron network	0.3056
p.G82E	KM12	large intestine	COSMIC	PPGY	ITCH	78:81	Mutation rewiring degron network	0.3056
p.S75Y	TCGA-DA-A1IB	SKCM	TCGA	PPGY	ITCH	78:81	Mutation rewiring degron network	0.25
p.S75Y	DO38033	SKCM	ICGC	PPGY	ITCH	78:81	Mutation rewiring degron network	0.25
p.G80C	DO229006	LICA	ICGC	PPGY	ITCH	78:81	Mutation altering degron motif	0.6489
p.P71H	DO232761	PBCA	ICGC	PPGY	ITCH	78:81	Mutation rewiring degron network	0.1389
p.V76M	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	78:81	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMARCD1

UniProt ID: Q96GM5

Entrez ID: 6602

Protein name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMARCD1 in