DegronMD - Q96GX8(C16orf74)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E24K	TCGA-EK-A3GK	CESC	TCGA	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1944
p.E24K	DO49964	CESC	ICGC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1944
p.M13I	DO228483	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.2778
p.M13I	SIDM01498	Acute Myeloid Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.2778
p.V27I	DO222973	BTCA	ICGC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1111
p.V27I	DO222737	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1111
p.D23E	DO15591	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.2222
p.P26H	DO228948	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1389
p.A28D	DO229045	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.0833
p.S17L	DO229459	SKCA	ICGC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation altering degron motif	0.7667
p.P26L	DO47331	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1389
p.P26L	SIDM01102	Non-Cancerous	GDSC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation rewiring degron network	0.1389
p.S17R	SIDM01727	Chronic Myelogenous Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	15:19	Mutation altering degron motif	0.7427

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons