DegronMD - Q96GY0(ZC2HC1A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L219F	TCGA-25-1326	OV	TCGA	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1389
p.L219F	DO28154	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1389
p.G202C	TCGA-A5-A0G1	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1667
p.G202C	DO42472	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1667
p.K106T	TCGA-AN-A046	BRCA	TCGA	PPSY	ITCH	112:115	Mutation substituting flanking lysine	0.2778
p.K106T	DO1285	BRCA	ICGC	PPSY	ITCH	112:115	Mutation substituting flanking lysine	0.2778
p.S209P	TCGA-AP-A0LM	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.5641
p.S209P	DO43306	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation altering degron motif	0.5641
p.P111L	TCGA-CN-5361	HNSC	TCGA	PPSY	ITCH	112:115	Mutation rewiring degron network	0.3056
p.P111L	DO14329	HNSC	ICGC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.3056
p.V200F	TCGA-DX-A8BX	SARC	TCGA	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1111
p.V200F	DO220068	SARC	ICGC	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1111
p.P204S	TCGA-DX-AB2E	SARC	TCGA	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.2222
p.P204S	DO220073	SARC	ICGC	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.2222
p.E103D	TCGA-EE-A3JB	SKCM	TCGA	PPSY	ITCH	112:115	Mutation rewiring degron network	0.0833
p.E103D	DO51250	SKCM	ICGC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.0833
p.G105D	TCGA-HT-7884	LGG	TCGA	PPSY	ITCH	112:115	Mutation rewiring degron network	0.1389
p.G105D	DO44555	LGG	ICGC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.1389
p.Q121K	TCGA-TN-A7HL	HNSC	TCGA	PPSY	ITCH	112:115	Mutation rewiring degron network	0.1667
p.Q121K	DO219080	HNSC	ICGC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.1667
p.P117T	DO228896	LICA	ICGC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.2778
p.C125F	DO229038	LICA	ICGC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.0556
p.G105V	DO229045	LICA	ICGC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.1389
p.L107R	DO228496	MALY	ICGC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.1944
p.D116H	DO224719	PACA	ICGC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.3056
p.G105A	DO224719	PACA	ICGC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.1389
p.V203A	SIDM02021	Esophageal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.1944
p.E103K	SIDM00282	Colorectal Carcinoma	GDSC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.0833
p.E103K	ACH-000998	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	112:115	Mutation rewiring degron network	0.0833
p.E103K	CW-2	large intestine	COSMIC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.0833
p.Q121R	SIDM01045	Endometrial Carcinoma	GDSC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.1667
p.Q121R	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	112:115	Mutation rewiring degron network	0.1667
p.Q121R	EN	endometrium	COSMIC	PPSY	ITCH	112:115	Mutation rewiring degron network	0.1667
p.K207E	ACH-002348	Non-Cancerous	CCLE	VSSSS	DEG_SPOP_SBC_1	208:212	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC2HC1A

UniProt ID: Q96GY0

Entrez ID: 51101

Protein name: Zinc finger C2HC domain-containing protein 1A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC2HC1A in