DegronMD - Q96I24(FUBP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P541S	TCGA-AD-6895	COAD	TCGA	PPDY	ITCH	540:543	Mutation altering degron motif	0.6752
p.P541S	DO8938	COAD	ICGC	PPDY	ITCH	540:543	Mutation altering degron motif	0.6752
p.P541S	DO223044	ESCA	ICGC	PPDY	ITCH	540:543	Mutation altering degron motif	0.6752
p.S539Y	TCGA-D3-A3C7	SKCM	TCGA	PPDY	ITCH	540:543	Mutation blocking phosphorylation signal	0.75
p.S539Y	DO47569	SKCM	ICGC	PPDY	ITCH	540:543	Mutation blocking phosphorylation signal	0.75
p.A531T	TCGA-DU-6407	LGG	TCGA	PPDY	ITCH	540:543	Mutation rewiring degron network	0.0833
p.A531T	DO22295	LGG	ICGC	PPDY	ITCH	540:543	Mutation rewiring degron network	0.0833
p.A530S	DO229018	LICA	ICGC	PPDY	ITCH	540:543	Mutation rewiring degron network	0.0556
p.A546S	DO229037	LICA	ICGC	PPDY	ITCH	540:543	Mutation rewiring degron network	0.25
p.A530T	DO48682	LIRI	ICGC	PPDY	ITCH	540:543	Mutation rewiring degron network	0.0556
p.S539F	DO220900	MELA	ICGC	PPDY	ITCH	540:543	Mutation blocking phosphorylation signal	0.75
p.A533T	SIDM00633	Breast Carcinoma	GDSC	PPDY	ITCH	540:543	Mutation rewiring degron network	0.1389
p.A533T	SIDM00493	Other Solid Cancers	GDSC	PPDY	ITCH	540:543	Mutation rewiring degron network	0.1389
p.Y543S	SIDM01079	Melanoma	GDSC	PPDY	ITCH	540:543	Mutation altering degron motif	0.8231
p.Y543S	ACH-000441	Skin Cancer	CCLE	PPDY	ITCH	540:543	Mutation altering degron motif	0.8231
p.Y543S	SH-4	skin	COSMIC	PPDY	ITCH	540:543	Mutation altering degron motif	0.8231
p.P541L	SIDM00217	Colorectal Carcinoma	GDSC	PPDY	ITCH	540:543	Mutation altering degron motif	0.7582
p.P541L	ACH-000999	Colon/Colorectal Cancer	CCLE	PPDY	ITCH	540:543	Mutation altering degron motif	0.7582
p.P541L	SNU-1040	large intestine	COSMIC	PPDY	ITCH	540:543	Mutation altering degron motif	0.7582

Kaplan plot for FUBP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FUBP3

UniProt ID: Q96I24

Entrez ID: 8939

Protein name: Far upstream element-binding protein 3 (FUSE-binding protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FUBP3 in