DegronMD - Q96IQ9(ZNF414)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S38F	TCGA-44-2659	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7982
p.S38F	DO23744	LUAD	ICGC	APSSS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7982
p.S42L	TCGA-A6-5661	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.S42L	TCGA-AP-A1DV	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.S42L	DO8634	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.S42L	DO43186	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.P45T	DO228974	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.1944
p.P45T	DO229022	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.1944
p.E26Q	ACH-000975	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons