DegronMD - Q96IT1(ZNF496)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D348H	TCGA-66-2783	LUSC	TCGA	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1111
p.R279C	TCGA-A5-A0G2	UCEC	TCGA	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.719
p.R279C	TCGA-BH-A0EI	BRCA	TCGA	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.719
p.R279C	ACH-001719	Ovarian Cancer	CCLE	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.719
p.L357I	TCGA-B5-A0JY	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.6063
p.A266T	TCGA-CK-4951	COAD	TCGA	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.1111
p.S360F	TCGA-D3-A8GO	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.7982
p.E349K	TCGA-DK-AA71	BLCA	TCGA	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1389
p.E349K	SW954	vulva	COSMIC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1389
p.E277Q	TCGA-DR-A0ZM	CESC	TCGA	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.6744
p.P369Q	TCGA-EE-A3AH	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.0833
p.D362A	TCGA-XF-A9ST	BLCA	TCGA	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2778
p.T352A	TCGA-XK-AAIW	PRAD	TCGA	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2222
p.E268K	DO50023	BRCA	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.1667
p.I287T	DO12100	GBM	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.2222
p.G292R	DO14175	HNSC	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.0833
p.N368K	DO228948	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1111
p.Q353H	DO26429	LUSC	ICGC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.25
p.D275N	DO45454	LUSC	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.6932
p.Y282C	DO218960	PAAD	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7087
p.T363M	DO49193	PACA	ICGC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.25
p.L273R	DO50284	SKCM	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.3056
p.P276S	DO50284	SKCM	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.6752
p.D270Y	DO229211	THCA	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.2222
p.R346K	DO43306	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.0556
p.R349C	DO223286	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1389
p.R349C	DO42472	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1389
p.V280F	SIDM01156	Small Cell Lung Carcinoma	GDSC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.V280F	SIDM00652	Small Cell Lung Carcinoma	GDSC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.V280F	ACH-000780	Lung Cancer	CCLE	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.V280F	ACH-000890	Lung Cancer	CCLE	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.V280F	SW1271	lung	COSMIC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.V280F	NCI-H1105	lung	COSMIC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.E290Q	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.1389
p.E290Q	ACH-000414	Lung Cancer	CCLE	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.1389
p.E290Q	NCI-H1944	lung	COSMIC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.1389
p.S271F	SIDM00545	Melanoma	GDSC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.25
p.S271F	ACH-000987	Skin Cancer	CCLE	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.25
p.S271F	Mewo	skin	COSMIC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.25
p.S358F	SIDM00082	Melanoma	GDSC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.7982
p.S358F	ACH-001190	Skin Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.7982
p.S358F	SK-MEL-2	skin	COSMIC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.7982
p.P292T	SIDM01193	Glioma	GDSC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.0833
p.P292T	ACH-000040	Brain Cancer	CCLE	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.0833
p.P292T	U-118-MG	central nervous system	COSMIC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.0833
p.L270F	SIDM00679	Cervical Carcinoma	GDSC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.2222
p.L270F	ACH-001525	Cervical Cancer	CCLE	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.2222
p.L270F	HT-3	cervix	COSMIC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.2222
p.D364V	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2222
p.D364V	ACH-000337	Lung Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2222
p.D364V	NCI-H3122	lung	COSMIC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2222
p.D364Y	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2222
p.D364Y	ACH-000337	Lung Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2222
p.D364Y	NCI-H3122	lung	COSMIC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2222
p.Y370F	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.0556
p.D348N	SIDM01442	Glioma	GDSC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1111
p.D348N	ACH-000807	Brain Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.1111
p.Q287E	ACH-001028	Rhabdoid	CCLE	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF496

UniProt ID: Q96IT1

Entrez ID: 84838

Protein name: Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF496 in