DegronMD - Q96IT1(ZNF496)

FUNCTION: DNA-binding transcription factor that can both act as an activator and a repressor. {ECO:0000250}.

GO - Biological processes (BP): positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]

GO - Molecular function (MF): DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]

GO - Cellular component (CC): nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
EENEPRVPEL	DEG_COP1_1	COP1	Zinc finger protein 496	274:283	More..
VLSSS	DEG_SPOP_SBC_1	SPOP	Zinc finger protein 496	356:360	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S360F	TCGA-D3-A8GO	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.7982
p.S358F	SIDM00082	Melanoma	GDSC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.7982
p.S358F	ACH-001190	Skin Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.7982
p.S358F	SK-MEL-2	skin	COSMIC	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.7982
p.R279C	TCGA-A5-A0G2	UCEC	TCGA	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.719
p.R279C	TCGA-BH-A0EI	BRCA	TCGA	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.719
p.R279C	ACH-001719	Ovarian Cancer	CCLE	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.719
p.Y282C	DO218960	PAAD	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7087
p.V280F	SIDM01156	Small Cell Lung Carcinoma	GDSC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.V280F	SIDM00652	Small Cell Lung Carcinoma	GDSC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.V280F	ACH-000780	Lung Cancer	CCLE	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.V280F	ACH-000890	Lung Cancer	CCLE	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.V280F	SW1271	lung	COSMIC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.V280F	NCI-H1105	lung	COSMIC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.7068
p.D275N	DO45454	LUSC	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.6932
p.P276S	DO50284	SKCM	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.6752
p.E277Q	TCGA-DR-A0ZM	CESC	TCGA	EENEPRVPEL	DEG_COP1_1	274:283	Mutation altering degron motif	0.6744
p.L357I	TCGA-B5-A0JY	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation altering degron motif	0.6063
p.L273R	DO50284	SKCM	ICGC	EENEPRVPEL	DEG_COP1_1	274:283	Mutation rewiring degron network	0.3056
p.D362A	TCGA-XF-A9ST	BLCA	TCGA	VLSSS	DEG_SPOP_SBC_1	356:360	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 58 entries

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No resistance data available for this Degron.

Kaplan plot for ZNF496 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF496

UniProt ID: Q96IT1

Entrez ID: 84838

Protein name: Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for ZNF496 in