DegronMD - Q96JA1(LRIG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A518V	TCGA-AX-A06F	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	518:522	Mutation altering degron motif	0.5825
p.A518V	DO41752	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	518:522	Mutation altering degron motif	0.5825
p.D511G	TCGA-CD-A4MG	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	518:522	Mutation rewiring degron network	0.1389
p.D511G	DO48009	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	518:522	Mutation rewiring degron network	0.1389
p.P525L	DO222404	BTCA	ICGC	AASSS	DEG_SPOP_SBC_1	518:522	Mutation rewiring degron network	0.25
p.S517L	DO233193	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	518:522	Mutation rewiring degron network	0.3056
p.R513W	SIDM02039	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	518:522	Mutation rewiring degron network	0.1944
p.R513W	SIDM00789	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	518:522	Mutation rewiring degron network	0.1944
p.R513W	HCT-15	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	518:522	Mutation rewiring degron network	0.1944
p.S524Y	SIDM01746	Osteosarcoma	GDSC	AASSS	DEG_SPOP_SBC_1	518:522	Mutation rewiring degron network	0.2778
p.S520N	ACH-000954	Endometrial/Uterine Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	518:522	Mutation altering degron motif	0.7069
p.C513R	SNU-81	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	518:522	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons