ZFYVE19
UniProt ID: Q96K21
Entrez ID: 84936
Protein name: Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent...
FUNCTION: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. {ECO:0000269|PubMed:24814515}.
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GO - Biological processes (BP):
abscission [GO:0009838]; cell division [GO:0051301]; mitotic cytokinesis checkpoint signaling [GO:0044878]; negative regulation of cytokinesis [GO:0032466]...
abscission [GO:0009838]; cell division [GO:0051301]; mitotic cytokinesis checkpoint signaling [GO:0044878]; negative regulation of cytokinesis [GO:0032466]
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GO - Molecular function (MF):
metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]...
metal ion binding [GO:0046872]; phosphatidylinositol-3-phosphate binding [GO:0032266]
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GO - Cellular component (CC):
centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; midbody [GO:0030496]...
centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; Flemming body [GO:0090543]; midbody [GO:0030496]
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ZFYVE19
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Kaplan plot for ZFYVE19 in
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*NOTE: the Kaplan plots were collected from OncoLnc