DegronMD - Q96KP1(EXOC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L909S	TCGA-AA-A010	COAD	TCGA	AASST	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.1389
p.T912I	TCGA-AD-5900	COAD	TCGA	AASST	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.2222
p.T924A	TCGA-AP-A059	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	916:920	Mutation blocking phosphorylation signal	0.6667
p.S906N	TCGA-BR-6452	STAD	TCGA	AASST	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.0556
p.Q910L	SIDM00652	Small Cell Lung Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.1667
p.Q910L	ACH-000780	Lung Cancer	CCLE	AASST	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.1667
p.Q910L	NCI-H1105	lung	COSMIC	AASST	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.1667
p.C913Y	SIDM01107	Melanoma	GDSC	AASST	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.25
p.C913Y	ACH-000465	Skin Cancer	CCLE	AASST	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.25
p.C913Y	SK-MEL-1	skin	COSMIC	AASST	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons