FUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethy...
FUNCTION: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself. {ECO:0000269|PubMed:11316813, ECO:0000269|PubMed:18438403, ECO:0000269|PubMed:20084102, ECO:0000269|PubMed:20118233, ECO:0000269|PubMed:22387026, ECO:0000269|PubMed:8457211}.
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GO - Biological processes (BP):
behavioral response to cocaine [GO:0048148]; cellular response to cocaine [GO:0071314]; cellular response to starvation [GO:0009267]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin organization [GO:0006325]; DNA methylation [GO:0006306]; DNA methylation on cytosine within a CG sequ...
behavioral response to cocaine [GO:0048148]; cellular response to cocaine [GO:0071314]; cellular response to starvation [GO:0009267]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin organization [GO:0006325]; DNA methylation [GO:0006306]; DNA methylation on cytosine within a CG sequence [GO:0010424]; fertilization [GO:0009566]; histone lysine methylation [GO:0034968]; histone methylation [GO:0016571]; long-term memory [GO:0007616]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron fate specification [GO:0048665]; organ growth [GO:0035265]; peptidyl-lysine dimethylation [GO:0018027]; phenotypic switching [GO:0036166]; regulation of DNA methylation [GO:0044030]; regulation of DNA replication [GO:0006275]; regulation of histone H3-K4 methylation [GO:0051569]; regulation of histone H3-K9 methylation [GO:0051570]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; spermatid development [GO:0007286]; synaptonemal complex assembly [GO:0007130]
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GO - Molecular function (MF):
C2H2 zinc finger domain binding [GO:0070742]; histone-lysine N-methyltransferase activity [GO:0018024]; histone methyltransferase activity (H3-K27 specific) [GO:0046976]; histone methyltransferase activity (H3-K9 specific) [GO:0046974]; p53 binding [GO:0002039]; promoter-specific chromatin binding [...
C2H2 zinc finger domain binding [GO:0070742]; histone-lysine N-methyltransferase activity [GO:0018024]; histone methyltransferase activity (H3-K27 specific) [GO:0046976]; histone methyltransferase activity (H3-K9 specific) [GO:0046974]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protein-lysine N-methyltransferase activity [GO:0016279]; RNA polymerase II transcription regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor binding [GO:0001222]; zinc ion binding [GO:0008270]
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GO - Cellular component (CC):
chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
chromatin [GO:0000785]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
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