DegronMD - Q96LD1(SGCZ)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S269Y	TCGA-06-5416	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1389
p.S269Y	DO10880	GBM	ICGC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1389
p.E248D	TCGA-17-Z042	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.S272I	TCGA-66-2758	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.S272I	DO26731	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.P262S	TCGA-CJ-4904	KIRC	TCGA	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6752
p.P262S	DO18213	KIRC	ICGC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.6752
p.G259E	TCGA-D3-A51G	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.7199
p.G259E	DO229470	SKCA	ICGC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.7199
p.G259E	DO47700	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.7199
p.P262L	TCGA-D3-A8GB	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.7582
p.P262L	DO50280	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation altering degron motif	0.7582
p.S270L	TCGA-EB-A3Y7	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.S270L	DO37499	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.N252S	TCGA-EY-A1GI	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.N252S	DO41211	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.S268Y	DO52687	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.P271H	SIDM00524	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0833
p.P271H	ACH-000703	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0833
p.P271H	DMS-79	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0833
p.S272N	SIDM01198	Burkitt's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.S272N	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.S272N	SIDM00583	Pancreatic Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.F250C	SIDM00193	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.F250C	ACH-000991	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.F250C	SNU-81	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.P271S	ACH-001568	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0833
p.G252V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1667
p.S257Y	HOP-92	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.L263M	HCT-15	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056

Kaplan plot for SGCZ in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SGCZ

UniProt ID: Q96LD1

Entrez ID: 137868

Protein name: Zeta-sarcoglycan (Zeta-SG) (ZSG1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SGCZ in