DegronMD - Q96M63(ODAD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D647Y	TCGA-06-5416	GBM	TCGA	PASST	DEG_SPOP_SBC_1	654:658	Mutation rewiring degron network	0.1389
p.D647Y	DO10880	GBM	ICGC	PASST	DEG_SPOP_SBC_1	654:658	Mutation rewiring degron network	0.1389
p.R646I	TCGA-78-7540	LUAD	TCGA	PASST	DEG_SPOP_SBC_1	654:658	Mutation rewiring degron network	0.1111
p.R646I	DO23810	LUAD	ICGC	PASST	DEG_SPOP_SBC_1	654:658	Mutation rewiring degron network	0.1111
p.G661C	TCGA-92-7341	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.6489
p.G661C	DO26677	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.6489
p.R669L	TCGA-D3-A2JG	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.1944
p.R669L	DO47613	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.1944
p.S650F	TCGA-EB-A41A	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	654:658	Mutation rewiring degron network	0.2222
p.S650F	TCGA-EB-A41A	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.0556
p.S650F	DO37429	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	654:658	Mutation rewiring degron network	0.2222
p.S650F	DO37429	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.0556
p.S656Y	TCGA-UC-A7PG	CESC	TCGA	PASST	DEG_SPOP_SBC_1	654:658	Mutation altering degron motif	0.712
p.S656Y	DO51615	CESC	ICGC	PASST	DEG_SPOP_SBC_1	654:658	Mutation altering degron motif	0.712
p.T652S	TCGA-UC-A7PG	CESC	TCGA	PASST	DEG_SPOP_SBC_1	654:658	Mutation rewiring degron network	0.2778
p.T652S	TCGA-UC-A7PG	CESC	TCGA	PGSST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.1111
p.T652S	DO51615	CESC	ICGC	PASST	DEG_SPOP_SBC_1	654:658	Mutation rewiring degron network	0.2778
p.T652S	DO51615	CESC	ICGC	PGSST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.1111
p.T530I	TCGA-YD-A89C	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7078
p.T530I	DO219501	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7078
p.V531I	DO222953	BTCA	ICGC	AGSST	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.3056
p.V531I	DO229053	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.3056
p.A521D	DO228974	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.1944
p.S517R	DO228974	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.0833
p.P654T	DO229031	LICA	ICGC	PASST	DEG_SPOP_SBC_1	654:658	Mutation altering degron motif	0.7031
p.P660L	ACH-001396	Metastasis	CCLE	PGSST	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7582
p.L516P	NCI-H1155	lung	COSMIC	AGSST	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.0556

Kaplan plot for ODAD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ODAD1

UniProt ID: Q96M63

Entrez ID: 93233

Protein name: Outer dynein arm-docking complex subunit 1 (Coiled-coil domain-containing protein 114)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ODAD1 in