DegronMD - Q96N46(TTC14)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G592V	TCGA-37-4130	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0556
p.E573K	TCGA-50-6595	LUAD	TCGA	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1944
p.E573K	DO23654	LUAD	ICGC	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1944
p.E585Q	TCGA-66-2759	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25
p.E585Q	DO27326	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25
p.D485N	TCGA-94-8490	LUSC	TCGA	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.D485N	DO52021	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S480C	TCGA-A5-A0G1	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation blocking phosphorylation signal	0.5556
p.S480C	DO42472	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation blocking phosphorylation signal	0.5556
p.E585A	TCGA-AP-A051	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25
p.E585A	DO42673	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25
p.S478Y	TCGA-AP-A1DV	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.0556
p.S478Y	DO43186	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.0556
p.V481G	TCGA-AX-A1CE	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.1389
p.V481G	DO42280	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.1389
p.S494F	TCGA-DA-A3F8	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation blocking phosphorylation signal	0.7222
p.S494F	DO37418	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation blocking phosphorylation signal	0.7222
p.K568N	TCGA-EO-A3AV	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation blocking ubiquitination signal	0.5
p.K568N	TCGA-IB-7651	PAAD	TCGA	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation blocking ubiquitination signal	0.5
p.K568N	DO46657	PAAD	ICGC	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation blocking ubiquitination signal	0.5
p.K568N	DO52412	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation blocking ubiquitination signal	0.5
p.S495F	DO229354	LAML	ICGC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	DO230659	LAML	ICGC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	DO231140	LAML	ICGC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM00993	Plasma Cell Myeloma	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM00064	Hepatocellular Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM01005	Acute Myeloid Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM00571	Pancreatic Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM00687	Gastric Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM00247	Gastric Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM00324	Neuroblastoma	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM00986	Head and Neck Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM00045	Gastric Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM01372	Pancreatic Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM00161	Biliary Tract Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.S495F	SIDM01575	Plasma Cell Myeloma	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.25
p.H499Y	DO229548	PRAD	ICGC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation rewiring degron network	0.1389
p.S480N	SIDM00072	Non-Cancerous	GDSC	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation blocking phosphorylation signal	0.5556
p.S480N	ACH-000206	Lymphoma	CCLE	VSSSS	DEG_SPOP_SBC_1	488:492	Mutation blocking phosphorylation signal	0.5556
p.K574T	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation substituting flanking lysine	0.3333
p.K574T	ACH-000186	Lung Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation substituting flanking lysine	0.3333
p.K574T	NCI-H2444	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation substituting flanking lysine	0.3333
p.L579F	SIDM00217	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.587
p.L579F	ACH-000999	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.587
p.L579F	SNU-1040	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.587

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTC14

UniProt ID: Q96N46

Entrez ID: 151613

Protein name: Tetratricopeptide repeat protein 14 (TPR repeat protein 14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTC14 in