DegronMD - Q96ND0(FAM210A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P106L	TCGA-EE-A2MU	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1389
p.P106L	DO37436	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1389
p.H89R	TCGA-VQ-A91E	STAD	TCGA	VFSSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.H89R	DO51784	STAD	ICGC	VFSSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.F92L	DO228978	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.25
p.Q85K	DO229038	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.0556
p.T105N	DO229045	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.1667
p.A100V	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VFSSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.3056
p.A100V	PF-382	haematopoietic and lymphoid tissue	COSMIC	VFSSS	DEG_SPOP_SBC_1	95:99	Mutation rewiring degron network	0.3056
p.V95I	ACH-000419	Myeloma	CCLE	VFSSS	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.7076
p.V95I	ACH-001541	Myeloma	CCLE	VFSSS	DEG_SPOP_SBC_1	95:99	Mutation altering degron motif	0.7076

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons